| Type of Document |
Dissertation |
| Author |
Branski, Ryan C
|
| URN |
etd-03072005-162623 |
| Title |
Vocal Fold Fibroblast Response to Mechanical Stress |
| Degree |
Doctor of Philosophy |
| Program |
Communication Science and Disorders |
| School |
School of Health and Rehabilitation Sciences |
| Advisory Committee |
| Advisor Name |
Title |
| Katherine Verdolini, Ph.D. |
Committee Chair |
| Clark A. Rosen, M.D. |
Committee Member |
| Patricia A. Hebda, Ph.D. |
Committee Member |
| Sudha Agarwal, Ph.D. |
Committee Member |
| Susan Shaiman, Ph.D. |
Committee Member |
|
| Keywords |
- fibroblast
- cyclic tensile strain
- extracellular matrix
- inflammation
- vocal fold
|
| Date of Defense |
2005-02-07 |
| Availability |
unrestricted |
Abstract
The role of exercise in vocal fold wound healing has been overlooked. Data from numerous other systems suggest a positive role of tissue mobilization to facilitate optimal wound healing and biomechanically superior tissue. The current study sought to investigate the potential role of mechanical signaling to attenuate the inflammatory and alter the synthetic properties of fibroblasts cultured from the vocal folds. Vocal fold fibroblasts were subjected to one of four conditions: no treatment, IL-1â alone, mechanical stress alone, or mechanical stress plus IL-1â. Results suggest that mechanical stress may limit the inflammatory phenotype of vocal fold fibroblasts in the short-term (4 hours), but not in the long-term (24 hours). In fact, 24 hours of mechanical stress may actually increase the inflammatory response. In addition, neither IL-1â nor mechanical stress had an effect on vocal fold fibroblast synthesis of extracellular matrix proteins. As a potential explanation for the current findings, it is hypothesized that the vocal folds may be more resilient to mechanical stress given the inherently stressful environment associated with phonation.
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| Files |
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56K Modem |
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Higher-speed Access |
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branskirc1_etd.pdf |
951.63 Kb |
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